Fig. 3: MuHV-4 infection reduces lung PVM loads independently of the humoral response. | Mucosal Immunology

Fig. 3: MuHV-4 infection reduces lung PVM loads independently of the humoral response.

From: A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies

Fig. 3

a–d Thirty days after i.n. Mock or MuHV-4 infection, BALB/c mice were vaccinated with FI-PVM Ags (or Ctrl Ags), then challenged i.n. with 3·102 PFU of PVM (or PBS) and euthanized 5, 6 or 7 days later. Experimental outline (a). Infectious PVM virions in lungs at days 5, 6 and 7 after PVM i.n. challenge (b). PVM genomic copies in lungs at day 6 after PVM challenge. Statistics are highlighted for differences between Mock/Ctrl Ags/PVM and MuHV-4/Ctrl Ags/PVM groups. (c). Neutralisation of purified PVM virions by diluted sera from BALB/c mice euthanized at day 6 after PVM i.n. challenge (d). Data are presented as means ± SEM (and individual values in c). *P ≤ 0.05 and ***P ≤ 0.001 (one-way ANOVA and Bonferroni post-tests). Data are representative of two independent experiments.

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