Fig. 2: P. intestinalis colonization alters the colitis susceptibility of WT SPF mice. | Mucosal Immunology

Fig. 2: P. intestinalis colonization alters the colitis susceptibility of WT SPF mice.

From: Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation

Fig. 2

a Body weight loss of WT mice harboring SPF and SPF + P microbiota during DSS colitis (2.1% w/v for 7 days). b Representative colonoscopy images of colitis severity performed on day 6 after colitis induction in SPF and SPF + P mice. c Colitis score on day 6 and day 9 of DSS colitis, based on five parameters: granularity of mucosal surface, vascular pattern, translucency of the colon mucosa, visible fibrin, and stool consistency. d Colon length and e histological evaluation of SPF and SPF + P mice measured during steady state (d0) and during DSS colitis (d7). f Representative images of H&E-stained distal colon sections of d0 and d7 of DSS colitis and g histological analysis of d7 distal colon sections by each scoring parameter. Results represent n = 4–8 mice/group as mean ± SEM from one out of three representative experiments. P values represent an unpaired nonparametric Mann–Whitney test. p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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