Fig. 1: Status switch and vital role of AMs in LPS-induced ALI mouse model. | Mucosal Immunology

Fig. 1: Status switch and vital role of AMs in LPS-induced ALI mouse model.

From: Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11blo to CD11bhi status during lung injury process

Fig. 1

a Change of different BALF cell populations during the ALI process; b Trends of IL-6, TNF, IL-12 and CCL2 release in ALI; c Comparison of different AM markers between sham-AMs and ALI-AMs (four biological repeats for each time point, two technical repeats); d Change of different BALF cell populations with ALI or sham treatment that received PBS- or clodronate-liposomes 24 h before ALI; e Influence of clodronate-induced AM depletion on ALI-related cytokine release; f Unbiased clusters of lung parenchyma cells based on gating strategy; g LPS-bind capacity of AMs in vivo implied by the MFI of LPS-FITC. Data of a, b are shown as means ± SEM (four biological repeats, two technical repeats), asterisk symbol indicates (*) compared with sham group; data of d, e are shown as means ± SEM (four and eight biological repeats for sham and ALI group, respectively, two technical repeats each); *0.01 < P < 0.05; **P < 0.01; ***P < 0.001.

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