Fig. 5: CD153+ polyfunctional Mtb300-specific CD4 T cells are phenotypically less activated and differentiated than CD153− polyfunctional cells. | Mucosal Immunology

Fig. 5: CD153+ polyfunctional Mtb300-specific CD4 T cells are phenotypically less activated and differentiated than CD153− polyfunctional cells.

From: Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis

Fig. 5

a Representative flow cytometry overlay plots of CD27, HLA-DR, KLRG1, and Eomes expression in CD153+ IL-2+ IFNγ + TNFα+ (pink) and CD153− IL-2+ IFNγ+ TNFα+ (black) Mtb300-specific CD4 T cells in one LTBI and one aTB participant. b Summary graph of the expression of CD27, HLA-DR, KLRG1, and Eomes in CD153+ IL-2+ IFNγ+ TNFα+ [CD153+] and CD153- IL-2+ IFNγ+ TNFα+ [CD153−] Mtb300-specific CD4 T cells in LTBI (left) and aTB (right) participants. Only CD153+ IL-2+ IFNγ+ TNFα+ and CD153- IL-2+ IFNγ+ TNFα+ subpopulations with more than 30 events were considered for phenotyping. Statistical comparisons were performed using a paired nonparametric Wilcoxon test. (****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05).

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