Fig. 6: Partial restoration of CD153+ Mtb300-specific CD4 T cells after antitubercular therapy (ATT). | Mucosal Immunology

Fig. 6: Partial restoration of CD153+ Mtb300-specific CD4 T cells after antitubercular therapy (ATT).

From: Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis

Fig. 6

a Comparison of the proportion of CD153-expressing Mtb300-specific CD4 T cells before (baseline, BL) and after 24 weeks of TB treatment (W24) in HIV- uninfected and HIV-infected patients. Statistical comparisons were performed using a paired nonparametric Wilcoxon test for longitudinal data and a Mann–Whitney test between groups. b Fold change in CD153+ Mtb300-specific CD4 T cells between BL and W24. Statistical comparison was performed using a nonparametric Mann–Whitney test. c Polyfunctional profile of Mtb300 CD4 responses pre and post ATT. The x-axis displays each response pattern, the composition of which is denoted with a dot indicative of the presence of CD153, IL-2, IFNγ, and TNFα. The median (gray bar) and interquartile ranges (box) are shown. Subsets accounting for less than 1% of the total Mtb300-specific CD4 T cell response are not displayed. Each response pattern is color‐coded, and data are summarized in the pie charts. A Wilcoxon rank-sum test was used to compare response pattern between groups (****P < 0.0001, ***P < 0.001, **P < 0.01). Statistical differences between pie charts were defined using a permutation test.

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