Fig. 6: mTOR inhibition impairs lung epithelial cell responses to flagellin in vivo. | Mucosal Immunology

Fig. 6: mTOR inhibition impairs lung epithelial cell responses to flagellin in vivo.

From: mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

Fig. 6

a, b Mice received rapamycin or vehicle 24 and 1 h prior to intranasal administration of flagellin or PBS and bronchial brushings were harvested 2 h after challenge for RNA extraction and qPCR analysis of the indicated genes. c CXCL1 and CXCL2 were measured in BAL fluid 2 h after the challenge with flagellin. Data are shown as box and whisker plots (n = 6 per group). p values were calculated using Student’s t test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. ns not significant.

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