Fig. 1: LTβR expression in neutrophils protects from DSS-colitis. | Mucosal Immunology

Fig. 1: LTβR expression in neutrophils protects from DSS-colitis.

From: Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils

Fig. 1

Colitis was induced in Ltbrfl/fl × Mrp8-Cre (LTβRΔN) and control littermates by cycles of 2.5% DSS for 5 days followed by 2 days of water and disease progression was monitored. a weight loss was monitored daily as % starting body weight. b Colon length on day 9. c H&E stained representative histology sections of distal colon at 20× (top; scale bar, 200 μm) and 40× (bottom, scale bar, 100 μm) magnification. d Blinded total histological score from distal colon. Representative immunohistochemical MPO staining (e) and quantification (f) of MPO-positive neutrophils from sections of distal colon tissue. Scale bar, 50 μm g Kaplan–Meier survival plots of the indicated groups during two cycles of DSS. Data representative of >3 independent experiments (a, c, e-g) or pooled data from three experiments (b, d). Student’s t test (b, d, f), two-way ANOVA (a, g). Error bars represent SEM.

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