Fig. 5: AHR deficiency impacts intestinal GPR15⁺ memory CD4⁺ T cells in competitive bone marrow chimeras.

a Bone marrow from Gpr15^gfp/+ Ahr^+/+ (CD45.1) and Gpr15^gfp/+ Ahr^−/− (CD45.1, CD45.2) are engrafted in lethally irradiated normal WT hosts (CD45.2). Tissues were harvested 6–10 weeks post injection. b, c Frequency and number of donor-derived GPR15 (GFP)⁺ memory CD44^hi, CD45RB^lo CD4⁺ T cells. d, e Frequency and number of naive CD44^lo, CD45RB^hi CD4⁺ T cells of host tissues. PLN peripheral lymph nodes, MLN mesenteric lymph nodes, PP Peyer’s patches, SI small intestine. Mean + SEM; n = 14, two-way ANOVA with Bonferroni posttest, *P < 0.05 ****P < 0.0001. Combined results of three independent experiments.