Fig. 7: Eosinophil-dependent changes to epithelial gene expression. | Mucosal Immunology

Fig. 7: Eosinophil-dependent changes to epithelial gene expression.

From: Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes

Fig. 7

RNA from adherent epithelial cells following 7 days of culture with or without eosinophils (Eos) and/or IL-13 was sequenced, and 7457 genes were detected in the dataset. a Of these, 2828 genes were identified as significant by ANOVA (FDR < 0.05) and were clustered via K means (K = 5). b Clusters of significant genes that were upregulated (cluster 4) or downregulated (cluster 5) in the presence of eosinophils were compared with differentially expressed genes in EoE biopsy tissue (EoE Transcriptome). c Representative genes that were significantly upregulated or downregulated with coculture. Data represent a single biological replicate with 2–3 technical replicates per condition. Data were analyzed by ANOVA with Tukey post-test; bars represent p < 0.05. Data shown in c are mean ± SD.

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