Table 1 Some of the attractive protein hits identified with downregulated and upregulated pathways upon Eh interaction with macrophages and their involvement in different biological processes.
Pathway | Proteins name | Gene name | Log2 (Mϕ + Eh:Mϕ) |
|---|---|---|---|
Autophagy | Ras-related protein Rab-8A | Rab8a | −2.487297773 |
Vesicle transport through interaction with t-SNAREs homolog 1B | Vti1b | −2.276415228 | |
Leucine-rich PPR motif-containing protein, mitochondrial | Lrpprc | −1.920352236 | |
Ubiquitin-like modifier-activating enzyme ATG7 | Atg7 | −1.879435719 | |
Eukaryotic translation initiation factor 4 gamma 2 | Eif4g2 | −1.869596238 | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Pip4k2a | −1.696330289 | |
DDRGK domain-containing protein 1 | Ddrgk1 | −1.375571523 | |
Casein kinase II subunit alpha | Csnk2a1 | −1.357825241 | |
Vacuolar protein-sorting-associated protein 13C | Vps13c | −1.329413427 | |
Nicotinamide phosphoribosyltransferase | Nampt | −1.264269882 | |
Nuclease-sensitive element-binding protein 1 | Ybx1 | −1.250989274 | |
Protein LYRIC | Mtdh | −1.240315772 | |
Vacuolar protein-sorting-associated protein 25 | Vps25 | −1.215713799 | |
Toll-interacting protein | Tollip | −1.134730445 | |
Mitochondrial import receptor subunit TOM40 homolog | Tomm40 | −1.121109901 | |
Vesicle-mediated transport | Apolipoprotein E | Apoe | −3.51414455 |
COP9 signalosome complex subunit 5 | Cops5 | −3.304576253 | |
Guanine nucleotide exchange factor for Rab-3A | Rab3il1 | −2.78061151 | |
Serine/threonine-protein phosphatase 6 regulatory subunit 1 | Ppp6r1 | −2.364162044 | |
Arf-GAP domain and FG repeat-containing protein 1 | Agfg1 | −1.862706338 | |
Sorting nexin-9 | Snx9 | −1.746180117 | |
Vesicle-fusing ATPase | Nsf | −1.562175701 | |
N-acetylglucosamine-6-sulfatase | Gns | −1.489078578 | |
Ras-related protein Rab-5B | Rab5b | −1.44575498 | |
ADP-ribosylation factor GTPase-activating protein 2 | Arfgap2 | −1.392212831 | |
Spectrin beta chain, non-erythrocytic 1 | Sptbn1 | −1.382889625 | |
Synaptosomal-associated protein;Synaptosomal-associated protein 23 | Snap23 | −1.316635909 | |
Endophilin-A2 | Sh3gl1 | −1.303009113 | |
AP-3 complex subunit sigma-1 | Ap3s1 | −1.267496341 | |
Ras-related protein Rab-14 | Rab14 | −1.212935361 | |
Tubulin alpha-1B chain | Tuba1b | −1.203070057 | |
Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed | Actb | −1.18590081 | |
Protein ERGIC-53 | Lman1 | −1.066276302 | |
Regulation of endopeptidase activity | Biquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 14 | Usp14 | 0.977023422 |
Cathepsin D | Ctsd | 0.98112199 | |
Importin-5 | Ipo5 | 1.03083043 | |
Mitochondrial fission 1 protein | Fis1 | 1.089226942 | |
Proteasome activator complex subunit 2 | Psme2 | 1.132905812 | |
Tyrosine-protein phosphatase non-receptor type 1 | Ptpn1 | 1.157819839 | |
40S ribosomal protein S6 | Rps6 | 1.172423508 | |
Superoxide dismutase [Cu-Zn] | Sod1 | 1.173319354 | |
Peroxiredoxin-6 | Prdx6 | 1.219586745 | |
Apoptosis-associated speck-like protein containing a CARD | Pycard | 1.291603558 | |
Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase | Gart | 1.325271271 | |
Ubiquitin-conjugating enzyme E2 K | Ube2k | 1.380064459 | |
Lysosome-associated membrane glycoprotein 1 | Lamp1 | 1.403758537 | |
Cystatin-B | Cstb | 1.624709202 | |
Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide | Pebp1 | 1.633663697 | |
E3 SUMO-protein ligase RanBP2 | Ranbp2 | 1.757492686 | |
GTP-binding protein SAR1b | Sar1b | 1.887954116 | |
Glutathione peroxidase 1;Glutathione peroxidase | Gpx1 | 2.001946325 | |
Legumain | Lgmn | 2.113433803 | |
Protein S100-A9 | S100a9 | 2.188211001 | |
Allograft inflammatory factor 1 | Aif1 | 2.227956663 | |
GTPase-activating protein and VPS9 domain-containing protein 1 | Gapvd1 | 2.287058517 | |
AP-2 complex subunit mu | Ap2m1 | 2.339736008 | |
Acidic leucine-rich nuclear phosphoprotein 32 family member B | Anp32b | 3.002324472 | |
Antigen processing and presentation of peptide antigen | 26S proteasome non-ATPase regulatory subunit 13 | Psmd13 | 0.96842258 |
Ras-related protein Rab-7a | Rab7a | 1.039419183 | |
Cytoplasmic dynein 1 light intermediate chain 1 | Dync1li1 | 1.117828004 | |
Proteasome subunit beta type-7 | Psmb7 | 1.243730004 | |
Macrophage mannose receptor 1 | Mrc1 | 2.327256216 |
