Fig. 1: 5-OP-RU treatment in Mtb-infected macaques does not enhance control of the infection.
From: Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
a Ten animals were infected with 120-150 colony forming units (CFU) of Mtb H37Rv. Starting 6 weeks post-infection, animals were intratracheally treated with PBS (n = 5) or 5-OP-RU (n = 5). Animals were necropsied at weeks 15 or 16 post-infection. b Percentage of remaining animals in the 2 groups were plotted against the weeks after Mtb infection. Three 5-OP-RU treated animals (DHLR, DHAJ, DHMK) were humanly euthanized early due to the development of severe pulmonary distress. c Three-dimensional volume renderings of PET/CT scans of each animal at week 5 and 11 post-infection and at necropsy. d The lung total [18F]-FDG uptake (total lesion glycolysis, TLG) value in PBS (left) and 5-OP-RU treated (right) animals. Bacterial loads in the granulomas (e) and spleens (f) shown in pooled animals by experimental group and individual animals euthanized early. Each symbol represents an individual tissue sample from indicated animal. Dotted line indicates limit of detection. *p < 0.05, ***p < 0.001.
