Fig. 4: 5-OP-RU treatment leads to MAIT cell dysfunction in Mtb infected macaques.
From: Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
a Example FACS plots of intracellular cytokine staining of MR1/5-OP-RU tetramer+ cells from the BAL (animal ID: DH4X) following in vitro stimulation with 5-OP-RU for 6 h. b Example FACS plots of intracellular cytokine staining of MAIT cells from the BAL following in vitro stimulation with 5-OP-RU. c, d Summary graphs of percentage of MAIT cells that are ether IFN-γ+, TNF-α+, IL-17A+ or GM-CSF+ in the BAL (b) or blood (c) following in vitro stimulation with 5-OP-RU or PMA/ionomycin (PMA/ION). e, f Graphs showing the percentage of MAIT cells that are ether IFN-γ+, TNF-α+, IL-17A+, or GM-CSF+ following in vitro stimulation with 5-OP-RU (d) or PMA/ionomycin (e) in the indicated tissues at necropsy. Each symbol represents an individual tissue sample from indicated animal. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
