Fig. 5: 5-OP-RU treatment of Mtb infected macaques does not enhance conventional adaptive immune responses.
From: Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
a Example FACS plots of intracellular cytokine staining of CD4 T cells from the BAL following in vitro stimulation with MTB300 peptide megapool. b Summary graphs of percentage of CD4 T cells in the BAL that are IFN-γ+TNF-α+ following in vitro stimulation. c Example FACS plots of intracellular cytokine staining of CD8 T cells from the BAL following in vitro stimulation with the MHC-I Mtb peptide megapool. d Summary graphs of percentage of CD8 T cells in the BAL that are IFN-γ+TNF-α+ following in vitro stimulation. Graphs showing the percentage of IFN-γ+TNF-α+ CD4 T cells (e) or CD8 T cells (f) in the indicated tissues at necropsy. Each symbol represents an individual tissue sample from indicated animal. g Mtb-specific antibody response following infection. Plasma levels of IgG specific to Mtb antigens were calculated by subtracting background values obtained in the pre-infection samples.
