Fig. 6: PD-1 blockade partially restores MAIT cell function but not expansion after 5-OP-RU+CpG vaccination in uninfected macaques.
From: Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
a Uninfected animals were treated intratracheally with 5-OP-RU+CpG along with either rhesus macaque IgG4 isotype control or primatized anti-PD-1 antibody. b Example FACS plots of PD-1 expression on MAIT cells in the BAL. c Summary graph showing the geoMFI of PD-1 on MAIT cells in the BAL. d Kinetics of the frequency of MAIT cells among CD3+ cells in the BAL. e Example FACS plots of Ki-67 expression on MAIT cells in the BAL from pre-treatment and week 1 post-treatment. f Percentage of Ki-67+ MAIT cells in the BAL. g Example FACS plots of Ki-67 expression on MAIT cells in the blood from pre-treatment and week 1 post-treatment. h Percentage of Ki-67+ MAIT cells in the blood. i Example FACS plots of intracellular cytokine staining of MAIT cells from the BAL following in vitro stimulation with 5-OP-RU. J Percentage of MAIT cells that are ether IFN-γ+, TNF-α+ or IL-17A+ in the BAL following in vitro stimulation with 5-OP-RU. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
