Fig. 2: In vivo activated granzyme B-deficient CD4+ T cells display increased pathogenicity.
From: Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells
1 × 105 CD4+CD45RBhi T cells from WT or Gzmb−/− donor mice were adoptively transferred into Rag2−/− recipient mice. a Mice were weighed weekly, and (b) monitored for signs of disease. Twenty-one days after transfer, (c) colon pathology was scored (left, representative micrographs; right, data summary), and (d) donor-cell reconstitution of the IEL compartment in the colon was determined. For (a), dotted lines represent untreated Rag2−/− mice. For (c) and (d) each dot represents an individual mouse. Data are representative of at least three independent experiments. n = 8–10. **P < 0.01; ***P < 0.001; ****P < 0.0001; Student’s t test.
