Fig. 7: A2A^−/− ILC2 show enhanced ability to induce lung inflammation.

a–e Lung ILC2s (CD45⁺Lin⁻CD90.2⁺ ST2⁺CD25⁺) were sorted from IL-33-treated WT or A2A^−/− mice and transferred into NCG mice, respectively, followed by IL-33 or PBS i.n. challenge for 3 consecutive days, mice were sacrificed 24 h after last challenge a. b The number of lung ILC2 in recipient NCG mice. c Eosinophils number in BALF of recipient mice. d The amount of IL-5 and IL-13 in BALF. e H&E staining of lung tissues (bars, 100 µm). Data are representative of two independent experiments (n = 4 for PBS groups, n = 6 for IL-33 groups). Error bars show mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001 by unpaired Student’s t test.