Fig. 4: Increased S-protein-triggered prostanoid response in post COVID-19 MDM. | Mucosal Immunology

Fig. 4: Increased S-protein-triggered prostanoid response in post COVID-19 MDM.

From: Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages

Fig. 4

a PCA of lipid mediators quantified in seronegative (n = 10) or post CoV (n = 29) MDM ± S-protein. Red and blue circles: 95% CI (LC-MS/MS at 3-5 months p.i). b Heatmap of lipid mediators produced by MDM (seronegative/ post CoV) ± S-protein; clustered with k-means using Pearson correlation. Data are shown as mean of seronegative (n = 10) or post CoV (n = 29) MDM. Concentrations of 12-HHTrE, TXB2, PGF2α and 19-HETE/ 5-HETE produced by MDM + S-protein, at 3-5 months (c) or 12 months (d) p.i.; d n = 4 (seronegative); n = 7 (post CoV). Dashed lines indicate average ctrl level of either seronegative (blue) or seropositive (red) MDM. Bar graphs are depicted as mean + SEM. Statistical significance was determined by Mann–Whitney test. *p < 0.05.

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