Fig. 7: Effect of calcitonin gene-related peptide (CGRP) or L-817,818 on corneal wound healing in resiniferatoxin (RTX)-treated mice.

a, c Effect of CGRP or L-817,818 on wound closure in resiniferatoxin (RTX)-treated mice after epithelial abrasion. Images on the left show staining of the wounded corneal area at each time point after epithelial abrasion with fluorescein sodium. The graphs on the right show the dynamic changes in the ratio of wounded area within the whole corneal area from vehicle-treated mice, RTX-treated mice, and RTX-treated mice administered CGRP (a, n = 6 mice per group) or L-817,818 (c, n = 6 mice per group). b, d Comparison of the number of dividing epithelial cells among vehicle-treated mice, RTX-treated mice, and RTX-treated mice administered CGRP at 18 h after epithelial abrasion (b, n = 6 mice per group) or L-817,818 (d, n = 6 mice per group). Data are presented as mean ± SD. *RTX-treated mice vs. vehicle-treated mice, ^†RTX-treated mice with CGRP or L-817,818 treatment vs. RTX-treated mice, ^‡RTX-treated mice with L-817,818 treatment vs. vehicle-treated mice, *^,†,‡P < 0.05, **^,††P < 0.01 and ***^,†††P < 0.001.