Fig. 6: ASVs in the progeny mice conventionalized with antibiotic-perturbed microbiota correlate with elevated CD4+ T cell production of IL-13 and IL-17A.
From: Influence of the early-life gut microbiota on the immune responses to an inhaled allergen
Spearman correlations were used identify the colonic ASVs from the offspring-recipient mice sensitized and challenged with HDM (Fig. 4a) that significantly correlate with lung CD4+ T cell production of a IL-13 and b IL-17A. Each row is an ASV that is significantly correlated with the frequency of cytokine produced by pulmonary Th cells. ASVs were considered based on nominal significance (p < 0.05). The heatmap includes 39 colonic samples from 22 unique mice all of which were sensitized and challenged with HDM. Samples are annotated by source of microbiota, sensitization, timepoint at which the sample was collected, and the body site (colon or fecal pellet). The heatmap is colored by scaled (z-score) ASV relative abundance.
