Fig. 3: Comparison of immune population clusters between control, allergen, and viral exacerbated mice. | Mucosal Immunology

Fig. 3: Comparison of immune population clusters between control, allergen, and viral exacerbated mice.

From: Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations

Fig. 3

a Myeloid, Natural killer T cells, and T-regulatory cell populations of each exacerbation group expressed as a percentage increase of SAL cell population levels, as determined by both their proportions among UMAP clustering and cell numbers in the lung (% of UMAP times cell numbers/mL of lung cells). b Heatmap of signature genes of clusters C5, C6, C7, C10, C12, C15, C16, C17, and C21. c Comparison of both regulon number and the percentage increase of accumulated regulon activity from SAL in myeloid cluster populations between control and exacerbation groups. d, e Clustered UMAP and heatmap analysis reveal the regulon activation spectra in myeloid immune cell clusters as presented by control and exacerbation groups.

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