Fig. 1: Origins, recruitment, and replenishment of resident macrophages in the bladder.

A schematic view of macrophage populations in the mouse through development from embryo to an aged mouse. Yolk sac-derived macrophages that are initially present in the bladder are replaced by macrophages derived from the fetal liver during the latter stages of embryogenesis, then bone marrow-derived macrophages after birth. Additional macrophage sub-populations are present in the bladders of aged mice.