Fig. 1: Structure of MBL- and SPD-based antigen carriers. | Mucosal Immunology

Fig. 1: Structure of MBL- and SPD-based antigen carriers.

From: A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity

Fig. 1

Schematic structure of the MBL and SPD collectin polymers. a Structural domains of MBL and SPD. CRD = carbohydrate-recognition domain. b MBL and SPD self-assembled collagen-like triple helixes formed by interchain cysteine bonds. c SPD cross-shaped dodecamer. d SPD and MBL “tulip-bouquet” octodecamers, adapted from9. e–f Schematic representation of the primary structure of the designed M40 (e) and S40 (f) monomers carrying selected Mtb antigens: crosslinking region (S), collagen-like region (Coll), neck region (N).

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