Fig. 5: Exogenous IL-22 treatment prevented the dysregulation of solute transporters and prevented fatal diarrhea. | Mucosal Immunology

Fig. 5: Exogenous IL-22 treatment prevented the dysregulation of solute transporters and prevented fatal diarrhea.

From: Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease

Fig. 5

a Volcano plot depicting protein expression changes on day 8 p.i. in IL-22.Fc treated mice compared to vehicle controls using MS based proteomics. b, c Immunoblot analyses of CAR1, CAR2, CAR4, SLC26A3, SLC12A2, ATP1B2, ATP1B1 and GAPDH (loading control) in various treatment groups. Data from individual mice shown in (b) and densitometric quantification shown in (c). d Sodium and chloride levels in fecal samples or in the serum on day 11 p.i. in various treatment groups (n = 10 mice per group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 determined as follows: one-way ANOVA with Dunnett’s multiple comparisons test (c, d). Horizontal bars represent the mean of the points shown (c, d).

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