Fig. 3
From: Impaired reward prediction error encoding and striatal-midbrain connectivity in depression
Correlation between number of depressive episodes, and (a) reward prediction error in the right striatum and (b) punishment prediction error in the habenula, in the MDD group. [Note: To evaluate the effect of number of MDEs on PE without potential confounds, these analyses were conducted while adjusting for length of current episode. Unstandardized residuals are shown in the figure; correlation plots with raw scores (with no covariates) are shown in the Supplementary Fig S6]. These correlations were significant even after controlling for both length of current episode and current depression severity (BDI scores) [right striatum: r = −0.60; p = 0.011 and habenula: r = 0.56; p = 0.018]. Information about number of episodes was missing for seven MDD individuals, so the sample size for this correlational analysis was N = 18. PE - prediction error.
