Fig. 4
From: Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum
Firing on longer delays was attenuated in cocaine animals. a Normalized average firing rates across neurons during reward delivery broken down by delays 1–5 s for control rats (n = 195; 6 rats). Activity is aligned to fluid-well entry in order to encompass time immediately upon entry in the fluid well at the start of each delay before reward delivery. Reward delivery is marked by arrows for each delay. Delays 1–5 s are represented by black to lightest gray lines with 1 s delay being black lines and lightest gray lines being 5 s delays. Figure includes both forced and free-choice trials. b Normalized average firing rates across neurons during reward delivery broken down by delays 1–5 s for cocaine rats (n = 103; 4 rats). Activity is plotted in the same manner as a. c Normalized average firing rates, divided by maximum firing rate on 1 s delays 500 ms after fluid-well entry. Control rats are plotted in black squares/lines, cocaine rats are plotted in gray circles/lines. Firing rates were normalized to determine how initial firing rates to the shortest long delay declined as they increased in 1 s intervals. d Normalized average firing rates, divided by maximum firing rate on 1 s delays during reward delivery epoch (250 ms before reward delivery to 1 s after reward delivery). Control rats are plotted in black squares/lines, cocaine rats are plotted in gray circles/lines
