Fig. 3
GSK6A corrects open field behavior and marble burying in Fmr1KO mice. a–c GSK6A normalized excess time spent in the center of an open field arena (a: two-way ANOVA with Tukey’s post hoc tests: p(drug) = 0.419, F(1,32) = 0.7; p(genotype) = 0.191, F(1,32) = 1.8; p(interaction) = 0.009, F(1,32) = 7.7; *p = 0.031, p(ko/veh-ko/6 A) = 0.07), as well as increased frequency to enter the center (b: two-way ANOVA with Tukey’s post hoc tests: p(drug) = 0.102, F(1,32) = 2.8; p(genotype) = 0.023, F(1,32) = 5.7; p(interaction) = 0.09, F(1,32) = 3.1; *p = 0.03, p(ko/veh-ko/6 A) = 0.09). The distance traveled in the open field arena did not differ between the groups (c: two-way ANOVA: p(drug) = 0.74, F(1,32) = 0.1; p(genotype) = 0.64, F(1,32) = 0.2; p(interaction) = 0.94, F(1,32) = 0.01). d GSK6A treatment reduced excessive marble burying in Fmr1KO mice to WT levels (two-way ANOVA, Tukey’s post hoc tests: p(drug) < 0.0001, F(1,39) = 20.8; p(genotype) = 0.230, F(1,39) = 1.5; p(interaction) = 0.011, F(1,39) = 7.1; *p = 0.040, #p < 0.0001)
