Fig. 1 | Neuropsychopharmacology

Fig. 1

From: Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation: a behavioral and computational analysis

Fig. 1

a Experimental timeline. Two cohorts of rats (each n = 24) were assessed for open field activity as a measure of anxiety followed by spatial-discrimination reversal learning. Rats in cohort 1 were trained to intravenously self-administer cocaine under short- and long-access schedules (ShA; LgA) while rats in cohort 2 (control group) responded for food reinforcement under identical schedules. Finally, rats in both cohorts were re-assessed for reversal learning prior to sacrifice and post mortem qRT-PCR. b, c Frequency distribution plots of ‘total trials to criterion’ for the cocaine and control rats. d qRT-PCR was used to assess gene expression in the OFC, dorsal and ventral striatum

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