Fig. 1: Dysregulation of miRNA expression in SCZ and BD OFC. | Neuropsychopharmacology

Fig. 1: Dysregulation of miRNA expression in SCZ and BD OFC.

From: Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics

Fig. 1

a, b Results from NanoString nCounter miRNA profiling from the 200 most highly expressed miRNAs in the OFC presented as a volcano plot. The x axis represents log2 fold changes and the y axis represents the p-value with 1.2-fold and p < 0.05 cutoff, respectively. Significantly more than 1.2-fold increased miRNAs are shown as red circles and significantly more than 1.2-fold downregulated as blue circles. Notice the significant elevation of several miRNAs in SCZ (a) and BD (b) with one miRNA reduced in SCZ. Altered miRNAs chosen to be validated with qRT-PCR are named in the graph. c–i Graphs showing mean ± SEM relative to the mean of unaffected controls let-7e and miR-30d-5p geometric mean (c), miR-223-3p (d), miR-132 (e), miR-330-3p (f), miR-1260 (g), miR-28-3p (h), and miR-193b-3p (i) levels in SCZ, BD, and controls based on mature miRNA qRT-PCR. Graphs in (d–i) are normalized to the geometric mean of unaltered in BD and SCZ miRNAs let-7e and miR-30d-5p (see also (c) and Materials and methods). Data from each case are also depicted in the graph as blue circles (control), green circles (BD), and red circles (SCZ). #0.05 < p <0.10, *p < 0.05, **p < 0.01, ***p < 0.001, based on a univariate general linear model that corrects for RIN, brain pH, PMI, and refrigeration interval.

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