Fig. 2: Alterations in glutamate receptor subunit, GABAergic, and inflammatory gene expression in the OFC are significantly associated with miR-223 changes in SCZ and BD. | Neuropsychopharmacology

Fig. 2: Alterations in glutamate receptor subunit, GABAergic, and inflammatory gene expression in the OFC are significantly associated with miR-223 changes in SCZ and BD.

From: Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics

Fig. 2

a, b, e Graphs showing mean ± SEM relative to the mean of unaffected controls mRNA levels in SCZ, BD, and control OFC for GRIA2 (a), GRIN2B (b), and NPTX2 (e) mRNAs, based on qRT-PCR and normalized to the unaltered in SCZ and BD 18S rRNA (see also Fig. S1 and Materials and methods). c–d, f Correlations between changes in miR-223 and GRIA2 (c), GRIN2B (d), and NPTX2 (f) mRNA expression in the OFC of subjects with SCZ and BD. Spearman’s correlation coefficients and two-tailed p-values are shown in the graphs. g, i, j Graph showing mean ± SEM relative to the mean of unaffected controls mRNA levels in SCZ, BD, and control OFC for SERPINA3 (g), C4 (i), and GAD1 (k) based on qRT-PCR and normalized to 18S rRNA. h, j, l Correlations between changes in miR-223 and SERPINA3 (h), C4 (j), and GAD1 (l) expression in the OFC of subjects with SCZ and BD. Data from each case are also depicted in the graph as blue circles (control), green circles (BD), and red circles (SCZ). Spearman’s correlation coefficients and two-tailed p-values are shown in the graphs. For (a–c, g–i) #0.05 < p < 0.10, *p < 0.05, **p < 0.01, ***p < 0.001, based on a univariate general linear model that corrects for RIN, brain pH, PMI, and refrigeration Interval. Data from each case are also depicted in the graph as blue circles (control), green circles (BD), and red circles (SCZ).

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