Table 2 Network metrics of regions showing significant intergroup differences in psychotic probands and their nonpsychotic relatives.

From: Brain gray matter network organization in psychotic disorders

Regions with altered network metrics

Nodal centrality metrics

Probands

(N = 326)/relatives (N = 315)

HC (N = 202)

ANCOVA

Mean ± SD

Mean ± SD

F

P*

Psychotic probands vs healthy controls

 STG, L

Efficiency

0.042 ± 0.012

0.045 ± 0.009

11.36

0.024

 STP, L

Efficiency

0.055 ± 0.006

0.056 ± 0.004

10.37

0.031

 STP, R

Efficiency

0.056 ± 0.006

0.058 ± 0.005

11.99

0.024

 MTG, L

Efficiency

0.059 ± 0.005

0.060 ± 0.004

9.55

0.038

Nonpsychotic relatives vs healthy controls

 MFG, R

Degree

3.67 ± 0.58

3.89 ± 0.60

10.43

0.009

 IFG_Orb, R

Degree

3.07 ± 0.81

3.30 ± 0.57

12.93

0.006

 PCG, L

Degree

3.11 ± 1.58

2.49 ± 1.49

17.17

0.004

 Hippocampus, L

Degree

6.18 ± 0.75

6.40 ± 0.62

12.57

0.006

 Pallidum, L

Degree

7.58 ± 1.16

7.93 ± 0.73

12.42

0.006

 Thalamus, L

Degree

3.42 ± 0.79

3.17 ± 0.55

12.39

0.006

 MFG, R

Efficiency

0.067 ± 0.004

0.069 ± 0.004

9.52

0.013

 IFG_Orb, R

Efficiency

0.062 ± 0.006

0.064 ± 0.004

9.07

0.018

 PCG, L

Efficiency

0.065 ± 0.010

0.061 ± 0.009

14.12

0.003

 Hippocampus, L

Efficiency

0.081 ± 0.005

0.082 ± 0.004

14.31

0.003

 Thalamus, L

Efficiency

0.068 ± 0.005

0.067 ± 0.003

9.12

0.018

  1. ANCOVA analysis of covariance, FDR false discovery rate, HC healthy controls, SD standard deviation, MFG middle frontal gyrus, MTG middle temporal gyrus, IFG_Orb orbital inferior frontal gyrus, PCG posterior cingulate gyrus, STG superior temporal gyrus, STP superior temporal pole, L left, R right
  2. *P-values that were corrected with FDR
Back to article page