Table 1 Representative transgenic mouse models commonly used to study Alzheimer’s disease (AD).
From: Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau
Model name | Gene(s) | Mutation(s) | Promoter | Background | Availability | Ref. |
|---|---|---|---|---|---|---|
J20 | huAPP770 | APP-Swe, Ind | PDGFB | C57BL/6 | The Jackson Laboratory: Stock No. 34836-JAX | [29] |
TgCRND8 | huAPP695 | APP-Swe, Ind | Ham Prnp | Hybrid C3H/He-C57BL/6 | Peter St. George-Hyslop | [193] |
Tg-SwDI | huAPP770 | APP-Swe, Dut, Iowa | Mo Thy1 | C57BL/6 | The Jackson Laboratory: Stock No. 34843-JAX | [194] |
APP23 | huAPP751 | APP-Swe | Mo Thy1 | C57BL/6 | The Jackson Laboratory: Stock No. 030504 | [26] |
Tg2576 | huAPP695 | APP-Swe | Ham Prnp | C57BL/6 x SJL; C57BL6 | Taconic: Stock No. 1349 | [195] |
APPPS1 | huAPP, huPSEN1 | APP-Swe; PS1-L166P | Mo Thy1 | C57BL/6J | Mathias Jucker | [196] |
APPswe/PSEN1dE9 (line 85) | mo/huAPP695, huPSEN1 | APP-Swe; PS1∆E9 | Mo Prnp | C57BL/6; C3H | The Jackson Laboratory: Stock No. 034829 | [197] |
5xFAD | huAPP, huPSEN1 | APP-Swe, Flo, Lon; PS1-M146L, L286V | Mo Thy1 | C57BL/6 x SJL; C57BL6 | The Jackson Laboratory: Stock No. 034840; Stock No. 034848 | [198] |
JNPL3 | huMAPT 4R0N | P301L | Mo Prnp | C57BL/6, DBA/2, SW mixed | Taconic: Stock no. 2508 | [199] |
hTau.P301S | huMAPT 4R0N | P301S | Mo Thy1.2 | CBAxC57BL/6 | Michel Goedert; LifeArc | [200] |
PS19 | huMAPT 4R1N | P301S | Mo Prnp | C57BL/6 x C3H | The Jackson Laboratory: Stock No. 008169 | [201] |
3xTg-AD | huAPP, moPsen1, huMAPT 4R0N | APP-Swe; MAPT-P301L; Psen1 M146V knock-in | Mo Thy1.2 | C57BL/6;129 | The Jackson Laboratory: Stock No. 34830-JAX | [202] |
