Fig. 1: Sensorimotor processing in WT, PCP-treated and A2AR−/− mice. | Neuropsychopharmacology

Fig. 1: Sensorimotor processing in WT, PCP-treated and A2AR−/− mice.

From: Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia

Fig. 1

The prepulse inhibition (PPI) impairment of the acoustic startle response (ASR) was assessed and expressed as percentage mean ± SEM (n = 10–15 animals) of inhibition of ASR at the indicated prepulse acoustic stimulus amplitudes (i.e., 70, 75 and 80 dB). *P < 0.05, **P < 0.01 and ***P < 0.001, one-way ANOVA followed by Dunnett’s post hoc test compared with WT (A2AR+/+) group. Two-way ANOVA (PP × phenotype/PCP) revealed a significant main effect of phenotype/PCP (F(2,117) = 22.65, P < 0.0001) and a nonsignificant effect of PP (F(2,117) = 2.616, P = 0.0774) or the interaction between both factors (F(4,117) = 0.5762, P = 0.6804).

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