Fig. 2 | Neuropsychopharmacology

Fig. 2

From: Phase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D1 receptor positive allosteric modulator in patients with schizophrenia

Fig. 2

Effect size difference over time in patients treated with ASP4345 relative to placebo for A auditory steady-state response; B mismatch negativity measurements. The effects of ASP4345 (3, 15, 50, and 150 mg) on days 1, 14, and 17 (3 days after the last dose of the dopamine D1 receptor PAM) for the evoked electrophysiological measures of the ASSR evoked effect size (top figure) and MMN effect size (bottom figure) in patients with schizophrenia/schizoaffective disorder. The effect size of difference between ASP4345 and placebo (calculated as the difference between mean change from baseline ASP4345 and placebo, multiplied by a multiplicand (for negative peaks the multiplicand = −1 and for the positive peaks the multiplicand = 1) and divided by the pooled standard deviation for the two treatment groups) was summarized by event-related potential component, electrode/composite, and by treatment group and visit.

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