Fig. 3: Differential expression in neurons of schizophrenia patients compared to controls. | Neuropsychopharmacology

Fig. 3: Differential expression in neurons of schizophrenia patients compared to controls.

From: Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients

Fig. 3

A Volcano plot showing log2 fold change between cases and controls. Genes are colored based on significance: red (454 differentially expressed genes (DEGs), 332 upregulated and 122 downregulated) and blue (not significant) with cutoffs of log2 FC > 0.5 or <−0.5 and BH FDR corrected p value < 0.05. B Heatmap of DEGs by sample. C Enrichment pathway analysis of DEGs using DAVID and Webgestalt (demonstrated by enrichment ratio) implicated a set of KEGG pathways related to the PI3K/GSK3 signaling pathway and extracellular matrix organization. D Gene expression of selected genes from the PI3K/GSK3 signaling pathway in hiPSC–neurons.

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