Fig. 2: Schematic of symptom dynamic paths and prognostic depressive symptoms. | Neuropsychopharmacology

Fig. 2: Schematic of symptom dynamic paths and prognostic depressive symptoms.

From: Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings

Fig. 2

A Symptom dynamic paths in patients in the training datasets (Mayo PGRN-AMPS and ISPC subjects). B Longitudinal variation in severity score of depressed mood (HDRS item) in patients starting in the A3 stratum at baseline. C Symptom clusters within patient strata (e.g., A1 at baseline), illustrating the grouping of prognostic symptoms. Fig. B, D, E, and F depict variations in depressed mood (prognostic symptom) and suicide ideation (nonprognostic symptom) in patients with antidepressants or placebo on symptom dynamic paths A3 → B3 → C3 (nonresponders at 8 weeks), A3 → B2 → C2 (responders without remission at 8 weeks), and A3 → B1 → C1 (remission at 8 weeks). In Fig. B, D, E and F, the solid blue lines in each figure represent the variations (mean changes) in prognostic symptom scores, and shaded regions around the mean illustrate their 95% confidence intervals (CIs). The boxplots and error bars represent the overall variability in prognostic symptom severity scores at each timepoint. Fig. B and D: Comprise all patients originating in stratum A3 in training and placebo datasets. The variations in prognostic and nonprognostic symptoms in testing data cohorts are visualized in Fig. E and F, respectively.

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