Table 2 Disorder-specific heritability attributable to common variants, SNP heritability of disorders partitioned across sQTLs and eQTLsa.
Diagnosis | Schizophrenia | Bipolar disorder | Major depression | Alzheimer’s disease |
|---|---|---|---|---|
N SNPs | 10,69,224 | 9,62,367 | 10,60,414 | 10,35,603 |
Observed h2 (se) | 0.4 (0.015) | 0.3 (0.018) | 0.05 (0.003) | 0.046 (0.009) |
Proportion sQTLs | 0.04 | 0.04 | 0.04 | 0.04 |
Observed sQTL h2 (se) | 0.08 (0.01) | 0.07 (0.01) | 0.05 (0.01) | 0.06 (0.04) |
sQTL enrichment (se) | 2.1 (0.26) | 1.7 (0.31) | 1.2 (0.26) | 1.5 (0.90) |
sQTL enrichment p | 3.3E−05 | 0.02 | 0.38 | 0.55 |
Bonferroni p | 9.8E−05 | 0.06 | 1 | 1 |
Proportion eQTLs | 0.06 | 0.06 | 0.06 | 0.06 |
eQTL h2 (se) | 0.11 (0.01) | 0.08 (0.01) | 0.05 (0.01) | 0.12 (0.04) |
eQTL enrichment (se) | 1.7 (0.18) | 1.3 (0.22) | 0.8 (0.17) | 2.0 (0.71) |
eQTL enrichment p | 9.00E−05 | 0.13 | 0.41 | 0.14 |
Proportion eQTLs not sQTLS | 0.02 | 0.02 | 0.02 | 0.02 |
eQTL h2 (se) | 0.03 (0.007) | 0.02 (0.009) | 0.01 (0.008) | 0.08 (0.032) |
eQTL enrichment (se) | 1.16 (0.27) | 0.81 (0.38) | 0.48 (0.31) | 3.33 (1.3) |
eQTL enrichment p | 0.54 | 0.62 | 0.10 | 0.05 |
