Table 5 Results of the univariate gray matter region of interest analysis of the insula and putamen.

Compared groups	Region of interest	Side	TFCE	p-FWE	k	x	y	z
TW-pre > TW-post	Insula	L	91.50	0.012	76	−38	−3	−12
		R	54.96	0.033	23	32	10	−16
	Putamen	L	466.55	<0.001	2005	−21	16	8
		R	395.31	<0.001	1409	27	−8	15
TW-pre > CG-women	Insula	L	63.21	<0.001	1926	−39	−3	−12
		R	52.58	<0.001	2299	34	15	−10
	Putamen	L	274.31	<0.001	2381	−21	10	12
		R	257.58	<0.001	2316	26	−4	14
TW-pre > CG-men	Putamen	L	203.55	<0.001	892	−21	15	9
		R	183.13	<0.001	576	28	−3	15
TW-post < CG-men	Putamen	L	100.64	0.001	1050	−14	9	−2
		R	70.60	0.001	1429	26	4	−8
	Insula	L	38.69	0.005	303	−42	14	−6
		L	30.99	0.010	124	−42	−8	4
		R	21.37	0.001	131	30	−18	20
TW-post < CG-women	Insula	R	114.58	0.021	99	34	−15	9
CGM > CG-women	Insula	R	109.23	<0.001	1789	39	16	3
		L	49.7	<0.001	1199	−44	14	−8
		L	13.07	0.004	48	−44	−14	8
	Putamen	R	100.11	<0.001	1972	27	6	−4
		L	81.13	<0.001	1509	−26	−4	−3

Table reports respective statistics of significant clusters of the group comparisons between transgender and cisgender individuals. Clusters resulted from group comparisons corrected for total intracranial volume, age, and sexual orientation.
For reasons of brevity no results below a threshold of k = 22 voxel have been reported.
TW transgender women, Cg cisgender, pre before hormone treatment, post after hormone treatment, L left, R right, k cluster size, dF degrees of freedom, TFCE threshold-free-cluster-enhancement with subsequent family-wise-error-correction. Coordinates are reported according to MNI-space.

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