Fig. 3: Levels of pathogenesis and convergent analysis.
From: Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders
a ASD can manifest or be investigated at multiple different levels, starting from a genetic variant (marked by red star) all the way to behavioral phenotypes. b A conceptual illustration of convergent analysis from risk genes to behavior in ASD, in which multiple independent risk genes are studied in parallel to triangulate on specific protein complexes, functional networks, cell types, and or/circuits that show overlap among functionally diverse risk genes. Figures adapted from Willsey et al. [13] and Sestan and State 2018 [156] with author permission.
