Fig. 1: Depicts the general modeling strategy used.

The first cross-lagged coefficient βCL1 represents the association between ADHD symptoms assessed at baseline and functional connectivity measured at follow-up that have been adjusted for functional connectivity measured at baseline. The cross-lag coefficient, βCL2, represents the association between functional connectivity measured at baseline and ADHD symptoms measured at follow-up that have been adjusted for baseline ADHD symptoms. Cross-sectional associations between functional connectivity and ADHD symptoms were also modeled (βCS1 and βCS2). Autoregressive coefficients represent the stability of ADHD problems (βAR1) and functional connectivity (βAR2) from baseline to follow-up. Covariates of no interest including mean study age, sex, and length of time between scans were also controlled for in the model (not shown).