Table 2 Neuropsychological domain-specific effects between impaired and spared cluster and healthy controls in discovery and validation sample.
From: Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?
Overall | Impaired vs. spared | Impaired vs. HC | Spared vs. HC | ||||||
|---|---|---|---|---|---|---|---|---|---|
T (max) | p (uncorr) | p (FDR) | p (FDR) | Cohen’s d | p (FDR) | Cohen’s d | p (FDR) | Cohen’s d | |
Discovery | |||||||||
Social cognition | 0.980 | 0.583 | 0.583 | – | – | – | – | – | – |
Working memory | 6.089 | <0.001 | <0.001*** | 0.004** | 0.68 | <0.001*** | 1.11 | 0.053 | 0.28 |
Processing speed | 10.070 | <0.001 | <0.001*** | <0.001*** | 1.90 | <0.001*** | 2.12 | 0.223 | −0.17 |
Executive functioning | 5.416 | <0.001 | <0.001*** | <0.001*** | −1.62 | <0.001*** | −0.78 | <0.001*** | 0.53 |
Attention | 8.756 | <0.001 | <0.001*** | <0.001*** | 1.02 | <0.001*** | 2.05 | <0.001*** | 0.65 |
Verbal memory | 10.385 | <0.001 | <0.001*** | <0.001*** | −1.39 | <0.001*** | −2.44 | 0.001** | −0.48 |
Visual memory | 8.423 | <0.001 | <0.001*** | <0.001*** | 1.45 | <0.001*** | 1.67 | 0.003** | −0.44 |
Salience | 2.646 | 0.022 | 0.023* | 0.175 | −0.28 | 0.913 | −0.02 | 0.003** | 0.45 |
Validation | |||||||||
Social_cognition | 2.824 | 0.012 | 0.014* | 0.008** | −1.13 | 0.010* | −0.75 | 0.159 | – |
Working_memory | 0.792 | 0.700 | 0.720 | – | – | – | – | – | – |
Processing_speed | 7.256 | <0.001 | <0.001*** | <0.001*** | 1.91 | <0.001*** | 2.48 | 0.007** | 0.50 |
Executive_functioning | 2.497 | 0.031 | 0.034* | 0.020* | 0.98 | 0.023* | 0.67 | 0.212 | – |
Attention | 0.249 | 0.965 | 0.965 | – | – | – | – | – | – |
Verbal_memory | 7.112 | <0.001 | <0.001*** | <0.001*** | −1.48 | <0.001*** | −2.51 | 0.050 | – |
Visual_memory | 8.628 | <0.001 | <0.001*** | <0.001*** | 2.29 | <0.001*** | 3.04 | 0.052 | – |
Salience | 3.533 | 0.001 | 0.001** | 0.008** | −1.12 | <0.001*** | −1.03 | 0.578 | – |
