Table 3 Demographical effects between impaired and spared cluster and healthy controls in discovery and validation sample.

From: Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?

 

Impaired

Spared

Overall

Impaired vs. spared

Impaired vs. HC

Spared vs. HC

 

Mean (sd)

Mean (sd)

T(max)/Z

p (uncorr)

p (FDR)

p (FDR)

p (FDR)

p (FDR)

Discovery

  N

41

67

      

  Age

23.5 (4.3)

25.8 (5.4)

2.015

0.106

0.109

–

–

–

  Years of Education

13.5 (3.2)

14.5 (3.3)

4.612

<0.001

<0.001***

0.135

<0.001***

0.002**

  Sexa

female = 16

female = 19

25.611

<0.001

<0.001***

0.302

0.009**

<0.001***

  Sitea,b

11/5/11/5/9

28/15/17/3/4

23.614

0.003

0.003**

0.046*

0.061

0.014*

  Ìllness duration in daysc

163.66 (153.82)

192.43 (205.69)

−0.770

0.440

0.440

–

–

–

  Chlorpromazine equivalentd

685.65 (1596.42)

196.95 (125.38)

1.940

0.052

0.100

–

–

–

Validation

  N

13

40

      

  Age

24.2 (5.3)

26.2 (6.7)

0.899

0.630

0.673

–

–

–

  Years of Education

14.3 (3.7)

14.0 (3.5)

3.594

<0.001

0.001**

0.858

0.081

0.001**

  Sexa

Female = 5

Female = 16

8.575

0.014

0.016*

1.000

0.140

0.017*

  Illness duration in daysc

149.00 (91.46)

198.53 (228.55)

−0.761

0.447

0.535

–

–

–

  Chlorpromazine equivalentd

127.80 (267.83)

1578.48 (6006.66)

−0.833

0.405

0.535

–

–

–

  1. HC healthy control, sd standard deviation, FDR False Discovery Rate.
  2. aNominal permutation test are used; Fisher’s exact p value is reported.
  3. bSites: Munich/Basel/Köln/Udine/Milan.
  4. cDifference in time between first fulfillment of psychotic diagnosis according to Structured Clinical Interview for DSM-IV (SCID) and date of MRI examination.
  5. dCumulative sum of chlorpromazine equivalents divided by the number of days treated.
  6. *p < 0.05, **p < 0.01, ***p < 0.001.
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