Table 1 Sample characteristics and group differences at baseline.

From: Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study

 

First-episode psychosis

Healthy control (N = 27)

T/χ2 (p)a

PIPT (N = 30)

MIPT (N = 29)

Baseline age, years (SD)

18.8 (2.72)

19.5 (2.94)

21.9 (1.93)

−4.49 (<0.001)

Females, N (%)

14 (46.6%)

13 (44.8%)

17 (62.9%)

2.19 (0.139)

Handedness, left, N (%)

2 (6.7%)

2 (6.9%)

3 (11.1%)

0.465 (0.495)

Education, years (SD)

11.8 (1.86)

12.7 (2.30)

15.2 (1.90)

−6.21 (0.001)

Diagnosis, N

  Major depression with psychosis

7

5

–

 

  Schizophreniform disorder

5

5

–

 

  Psychotic disorder NOS

8

7

–

 

  Substance-induced psychotic disorder

4

2

–

 

  Delusional disorder

1

4

–

 

  Schizophrenia

5

5

–

 

  Missing diagnosis

0

1

–

 

Baseline BPRS total, mean (SD)

59.4 (9.64)

55.8 (10.10)

–

1.40 (0.166)

Baseline SOFAS, mean (SD)

52.9 (14.0)

51.7 (10.6)

–

0.384 (0.703)

Baseline SANS, mean (SD)

37.3 (17.2)

32.9 (18.1)

–

0.961 (0.346)

Baseline HAM-D, mean (SD)

19.5 (6.75)

18.2 (6.57)

–

0.745 (0.459)

Baseline HAM-A, mean (SD)

22.2 (6.42)

20.2 (7.25)

–

1.118 (0.268)

Baseline QLS, mean (SD)

68.5 (24)

70.6 (20.8)

–

−0.368 (0.714)

  1. PIPT placebo plus intensive psychosocial therapy, MIPT antipsychotic medication plus intensive psychosocial therapy, NOS not otherwise specified, BPRS Brief Psychiatric Rating Scale version 4, SOFAS Social and Occupational Functioning Assessment Scale, SANS Scale for the Assessment of Negative Symptoms, HAM-D Hamilton Depression Rating Scale, HAM-A Hamilton Anxiety Rating Scale, QLS Quality of Life Scale.
  2. aThis column provides the T or χ2 values comparing the healthy control and patients (collapsed across two treatment conditions) at baseline.
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