Fig. 1: Differences between groups in symptom severity and hormonal levels.

Descriptive panel showing the effect of SPRM treatment in comparison with placebo, according to the Daily Record of Severity of Problems (DRSP) total score (d = 1.09) (A), the four subscales, depression, anxiety, affective lability, and irritability (B), and hormone levels, indicated by the mean concentrations of estradiol, progesterone, and testosterone (C). Error bars indicate 95% confidence intervals. *: p ≤ 0.05; ¤: p ≤ 0.1.