Table 1 Characterization of the discovery sample and clusters.
From: Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning
Variable | Discovery | Cluster 0 | Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 |
|---|---|---|---|---|---|---|
N | 1250 | 535 | 38 | 266 | 215 | 196 |
Demographics | ||||||
Age, mean (SD) | 35.1 (13.0) | 31.7 (11.9) | 38.6 (13.9) | 35.3 (12.7) | 37.9 (13.7) | 40.3 (12.8) |
Male gender, N (%) | 483 (39%) | 205 (38%) | 9 (24%) | 106 (40%) | 74 (34%) | 89 (45%) |
Years of education, mean (SD) | 13.5 (2.6) | 14.4 (2.4) | 13.3 (2.6) | 13.8 (2.6) | 13.1 (2.8) | 12.1 (2.7) |
Living with partner, N (%) | 277 (28%) | 108 (20%) | 7 (18%) | 51 (19%) | 62 (29%) | 49 (25%) |
BMI, mean (SD) | 25.3 (5.5) | 23.7 (4.3) | 24.9 (5.1) | 24.8 (4.9) | 27.0 (6.6) | 28.1 (6.4) |
Family history (any psychiatric disorder), N (%) | 533 (43%) | 141 (26%) | 16 (42%) | 148 (56%) | 105 (49%) | 123 (63%) |
Diagnosis | ||||||
Age at onset (AAO)*, mean (SD) | 25.2 (11.9) | 24.5 (9.9) | 29.6 (13.3) | 23.3 (11.5) | 27.8 (12.8) | 24.4 (11.4) |
HC, N (%) | 590 (47%) | 448 (84%) | 19 (50%) | 78 (29%) | 34 (16%) | 11 (6%) |
BD, N (%) | 75 (6%) | 9 (2%) | 1 (3%) | 15 (6%) | 26 (12%) | 24 (12%) |
MDD, N (%) | 477 (38%) | 56 (10%) | 17 (45%) | 152 (57%) | 147(68%) | 105 (54%) |
SCZ, N (%) | 53 (4%) | 4 (1%) | 1 (3%) | 8 (3%) | 3 (1%) | 37 (19%) |
SZA, N (%) | 25 (2%) | 2 (0.3%) | 0 (0%) | 5 (2%) | 2 (1%) | 16 (8%) |
Other, N (%) | 30 (2%) | 16 (3%) | 0 (0%) | 8 (3%) | 3 (1%) | 3 (2%) |
Quality of life (SF36), mean (SD) | ||||||
General health | 66 (23.4) | 81.2 (14.0) | 57.9 (26.6) | 64.7 (19.8) | 49.4 (20.7) | 45.8 (21.3) |
Mental health | 64.3 (22.6) | 81.4 (9.8) | 55.6 (23) | 59.4 (18.9) | 46.4 (19.3) | 45.6 (21.3) |
Depression and anxiety, mean (SD) | ||||||
HAMA sum | 7.3 (7.9) | 2.2 (2.5) | 9.7 (8.6) | 7.6 (6.4) | 13.1 (8.6) | 14 (8.8) |
HAMD sum | 5.4 (6.6) | 1.1 (1.6) | 6.3 (6.7) | 5.9 (5.7) | 9.9 (7.0) | 11 (7.5) |
BDI sum | 10.7 (10.8) | 3.2 (3.3) | 15.1 (12.8) | 12.7 (9.6) | 17.6 (10.1) | 20.3 (11.7) |
Positive, negative, and manic symptoms, mean (SD) | ||||||
SANS | 5.7 (9.9) | 0.6 (1.7) | 5.2 (8.6) | 6.9 (9.6) | 8.0 (9.1) | 15.6 (14.4) |
SAPS | 1.4 (5.2) | 0.1 (0.6) | 0.1 (0.4) | 0.6 (1.6) | 0.7 (1.8) | 6.7 (11.5) |
YMRS | 1.2 (2.5) | 0.5 (1.1) | 0.8 (1.4) | 1.1 (1.8) | 1.3 (2) | 2.9 (4.9) |
Maltreatment in childhood and youth (CTQ), mean (SD) | ||||||
Emotional abuse | 9.1 (4.7) | 6.3 (1.7) | 9.9 (4.9) | 11.4 (4.2) | 8.0 (3.0) | 14.6 (5.9) |
Emotional neglect | 10.7 (5.2) | 7.5 (2.6) | 11.8 (5.4) | 14.1 (4.1) | 9.2 (3.5) | 16.5 (5.4) |
Physical abuse | 6.2 (2.6) | 5.3 (0.7) | 6.4 (2.2) | 6.4 (2) | 5.5 (1.1) | 9.5 (4.6) |
Physical neglect | 7.2 (2.7) | 5.8 (1.4) | 7.2 (2.2) | 8.0 (2.2) | 6.4 (1.6) | 10.4 (3.7) |
Sexual abuse | 5.8 (2.5) | 5.1 (0.4) | 5.8 (2) | 5.8 (1.9) | 5.6 (1.7) | 8.0 (4.9) |
