Fig. 4: Individual subject heatmaps plotting dlPFC predictions for the anxious misery group. | Neuropsychopharmacology

Fig. 4: Individual subject heatmaps plotting dlPFC predictions for the anxious misery group.

From: Proof of concept study to develop a novel connectivity-based electric-field modelling approach for individualized targeting of transcranial magnetic stimulation treatment

Fig. 4

A, C, E, G Heatmaps representing the predicted MADRS and HAMD scores following a hypothetical course of TMS treatment to the left dlPFC. B, D, F, H Heatmaps representing the predicted MADRS/HAMD scores following a hypothetical course of TMS treatment to the right dlPFC. Colors represent the predicted change in MADRS/HAMD scores. Y-axis represents coil orientation. X-axis represents location along the Z-axis of the middle frontal gyrus. The center point of the shaded circle on the heatmaps represents the site and orientation of stimulation predicted to have the maximal reduction in symptoms for each subject. The area of the shaded circle represents the variability (i.e., Euclidean distance [95% confidence interval]) in this optimal site assessed using bootstrapping. sGACC = site along vector with maximal anti-correlation with the subgenual anterior cingulate cortex.

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