Fig. 3: EEG power density during NREM and REM sleep.

EEG power density (mean and 95% confidence intervals) a averaged across the entire night and expressed relative to placebo, and b averaged across the first third of the night and expressed relative to baseline (blue circles indicate 20 mg, red circles indicate 50 mg, black circles indicate baseline, open circles indicate placebo). Horizontal lines indicate significant differences between JNJ-48816274 treatment (20 and 50 mg) and placebo (*p < 0.05 and **p < 0.01).