Fig. 3: Opioid craving dynamics.

A Momentary reported opioid craving (% of scale’s max) by study day (after 24 h from methadone dosing and shortly after dosing; randomized order) and task block (up to four) within a day. Craving was higher 24 h after methadone dosing and varied substantially both between- and within-person across the task blocks (intraclass correlation coefficient = 0.56). B Within-person variability in reported craving (range in opioid craving ratings; gray points show single-participant data) was comparable across blocks within a day to variability across days. ***P = 0.001, n.s. nonsignificant.