Table 2 Tested phenotypes in GERA and association results with AUD PRS.

From: Genome-wide meta-analysis of alcohol use disorder in East Asians

Traits

Distribution

Beta (SE)

p value

Alcohol use in days per week

1 = 2757, 2 = 603, 3 = 503, 4 = 159, 5 = 267c

0.43 (0.07)

2.47 × 10−10

Smoking in pack years

0 = 3232, 1 = 530, 2 = 306, 3 = 128, 4 = 44d

0.09 (0.05)

4.52 × 10−2

Ever vs. never smoked

1 = 1055, 0 = 3232

0.06 (0.02)

1.14 × 10−2

Former vs. current smoker

1 = 924, 0 = 131

−0.04 (0.04)

2.50 × 10−1

Physical activity

1 = 897, 2 = 958, 3 = 1181, 4 = 1323e

0.02 (0.06)

7.97 × 10−1

Health status

1 = 740, 2 = 1506, 3 = 1625, 4 = 476 f

0.03 (0.05)

5.23 × 10−1

Disease or conditions

 Acute reaction to stress

1 = 275, 0 = 4189

−0.01 (0.01)

5.22 × 10−1

 Allergic rhinitis

1 = 1307, 0 = 3157

0.01 (0.03)

5.62 × 10−1

 Asthma

1 = 654, 0 = 3810

−0.01 (0.02)

7.21 × 10−1

 Cancer: anya

1 = 529, 0 = 3935

−0.00 (0.02)

9.36 × 10−1

 Cardiovascular disease: anyb

1 = 688, 0 = 3776

−0.03 (0.02)

1.48 × 10−1

 Major depressive disorder

1 = 262, 0 = 4202

0.01 (0.01)

3.66 × 10−1

 Dermatophytosis

1 = 374, 0 = 4090

−0.01 (0.02)

4.87 × 10−1

 Type II diabetes

1 = 729, 0 = 3735

0.03 (0.02)

9.65 × 10−2

 Dyslipidaemia

1 = 2192, 0 = 2272

−0.02 (0.03)

5.17 × 10−1

 Hemorrhoids

1 = 716, 0 = 3748

0.01 (0.02)

6.19 × 10−1

 Hernia abdominopelvic cavity

1 = 177, 0 = 4287

0.00 (0.01)

7.54 × 10−1

 Hypertensive disease

1 = 2028, 0 = 2436

−0.00 (0.02)

9.52 × 10−1

 Insomnia

1 = 185, 0 = 4279

−0.01 (0.01)

2.30 × 10−1

 Iron deficiency anemias

1 = 118, 0 = 4346

0.00 (0.01)

9.14 × 10−1

 Irritable bowel syndrome

1 = 103, 0 = 4361

0.00 (0.01)

7.05 × 10−1

 Macular degeneration

1 = 130, 0 = 4334

−0.00 (0.01)

7.94 × 10−1

 Osteoarthritis

1 = 941, 0 = 3523

−0.01 (0.02)

6.72 × 10−1

 Osteoporosis

1 = 392, 0 = 4072

0.01 (0.01)

6.46 × 10−1

 Psychiatric disorder: any

1 = 433, 0 = 4031

−0.00 (0.02)

9.93 × 10−1

 Peripheral vascular disease

1 = 160, 0 = 4304

0.01 (0.01)

3.81 × 10−1

  1. If not specified for distribution, 1 is case and 0 is control. Traits with p value < 0.05 are labled in bold font..
  2. aCancer: includes malignant tumors, neoplasms, lymphoma and sarcoma.
  3. bHeart disease: includes ischemic heart disease, cardiac arrest, congestive health failure, dysrhythmias, cardiomyopathy, aortic aneurysm, and cerebrovascular disease, but excludes PVD which is encompassed by the PVD variable.
  4. cDays of alcohol intake per week, 1 is no days, 2 is 1 day, 3 is 2–4 days, 4 is 5–6 days, 5 is every day.
  5. dPack years for former or current smoker, 0 = 0, 1 < 10, 2 = 10–20, 3 = 20–30, 4 ≥ 30.
  6. ePhysical activity total metabolic equivalency of task (MET), 1 = first quartile, 0–173 for males and 0–74 for females, 2 = second quartile, 174–600 for males and 75–344 for females, 3 = third quartile, 601–1380 for males and 345–983 for females, 4 = fourth quartile, 1381+ for males and 984+ for females.
  7. fHealth status, 1 = excellent, 2 = very good, 3 = good, 4 = fair.
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