Fig. 3: Acute autonomic effects of lysergic acid diethylamide (LSD) and psilocybin over time. | Neuropsychopharmacology

Fig. 3: Acute autonomic effects of lysergic acid diethylamide (LSD) and psilocybin over time.

From: Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects

Fig. 3

The 100 and 200 µg doses of lysergic acid diethylamide (LSD) only moderately increased blood pressure compared with placebo, whereas 15 and 30 mg psilocybin induced more pronounced increases in blood pressure. The 100 and 200 µg doses of LSD markedly increased heart rate, whereas only the higher 30 mg dose of psilocybin induced a moderate increase in heart rate compared with placebo. Both the 100 and 200 μg LSD doses and the 15 mg psilocybin dose increased body temperature moderately and similarly, whereas 30 mg psilocybin induced a more pronounced increase in body temperature compared with all other conditions. LSD (100 or 200 µg), psilocybin (15 or 30 mg), or placebo was administered at t = 0 h. The data are expressed as the mean ± SEM in 28 subjects. Maximal effects and statistics are shown in Supplementary Table S5.

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