Fig. 2: Time-blockade curves for exemplified bolus doses of intravenous (IV) naloxone, accounting for distribution to the brain and truncated at 100% blockade. | Neuropsychopharmacology

Fig. 2: Time-blockade curves for exemplified bolus doses of intravenous (IV) naloxone, accounting for distribution to the brain and truncated at 100% blockade.

From: Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade

Fig. 2

The dashed horizontal line indicates full (90%) receptor blockade. DOR (dot-dashed red curve) and KOR blockade (long-dashed blue curve) were approximated from MOR blockade (solid black curve) using the relative receptor affinities of naloxone (Table S1).

Back to article page